Introduction to Laser Optoacoustic Imaging System (LOIS-3D)
Summary: LOIS-3D
-
3D full view of a mouse body and brain with the best on the market optical absorption contrast, dma~0.03/cm (~1pmole of ICG)
-
3D Anatomical Imaging provides accurate image reconstruction with resolution <0.200 mm in focal area, <0.280 mm in ROI periphery
-
Most accurate approach to quantitative imaging
-
Rapid image acquisition (~40 sec) and reconstruction (~60 sec)
-
Spectroscopic capability by scanning through multiple wavelengths or rapid cycling of 2 or 3 wavelengths for differential imaging
-
Functional Imaging 3D
-
Measurement of total hemoglobin [tHb] and blood oxygenation [SO2] in tissues and blood vessels, assessment of blood flow.
-
Assessment of tumor angiogenesis, angiography, detection and characterization of stroke and traumatic injury of the brain
-
Molecular Imaging 3D
-
Distribution of cellular receptors with targeted nanoparticle agents
-
Studies into kinetic and dynamic distribution of contrast agents
-
Monitoring reporter gene activity in live animals
Optoacoustic System Specifications
-
Contrast / sensitivity to variation in optical absorption: 0.03 [1/cm]
-
Spatial resolution: 0.15 - 250 mm
- Time of 3D scan: 40 sec
-
Image volume (max): 30 x 30 x 30 mm
-
Post-processing with custom segmentation and measurements in segmented volumes
-
Mathematical imaging processing including: Sum, difference, multiplication, division to obtain functional and molecular images
-
3D video output, 2D slices in XYZ coordinates
Specifications of LOIS-3D system imaging principle: Full View 3D OAT
-
120 deg arc array of ultra-wideband 0.1 to 8 MHz transducers, 34560 or more virtual transducers on 65 mm diameter spherical surface = rigorous reconstruction
-
Minimal Time of Image acquisition: 36 sec min time of image acquisition + 42 sec image reconstruction 25x25x30mm